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George Mason University

Faculty & Staff Directory

Patricia Sinclair

  • Assistant Professor, Interdiscplinary Program in Neuroscience

    Contact Info

    Dr. Patricia Sinclair
    Name
    Dr. Patricia Sinclair
    Preferred Pronouns
    she/her
    Job Title
    Assistant Professor, Interdiscplinary Program in Neuroscience
    Phone Number
    703-993-3574
    Office Number
    KB 207

    Affiliations

    Departments

    Research Areas

    • Neuroscience

    Education

    PhD Neuroscience, George Mason University
    BS Neuroscience, George Mason University
    BS Cell Biology and Molecular Genetics, University of Maryland

    About

    I earned my PhD in Neuroscience with a focus on cellular and molecular mechanisms of neurodegenerative disease, particularly proteomic changes in neural cells. I teach introductory and advanced neuroscience courses, integrating hands-on activities and inclusive pedagogy to foster student engagement and success. I am committed to lifelong learning and to continually refining my teaching strategies to support diverse learners and inspire future scientists.

    Current Research

    My current research explores mitochondrial dysfunction, nicotinic receptor signaling, and neuroinflammation. In recent collaborative work, I applied machine learning to predict cannabinoid effects based on microglial oxidative stress. I am also interested in mitochondrial proteomes and the regulation of amyloid beta in neural cells.

     


     

    Teaching Focus

    NEUR 101 Intro to Neuroscience
    NEUR 327 Cellular Neuroscience
    NEUR 411 Seminar in Neuroscience 

    Selected Publications

    Patricia Sinclair, Navdeep S Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani “Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol.” Journal of Neuroendocrinology. 2025;e70033. doi:10.1111/jne.70033

    Patricia Sinclair, William Jeffries, Nadege Lebert, Maheen Saeed, Aman Ullah, Nadine Kabbani. “Predictive machine learning model for cannabinoid effect based on image detection of reactive oxygen species in microglia.” PLOS One. 2025, Mar 25;20(3):e0320219.doi: 10.1371/journal.pone.0320219. PMID: 40131976 PMCID: PMC11936260

    Aya Nusir, Patricia Sinclair, Nadine Kabbani. “Mitochondrial proteomes in neural cells: A systematic review.” Biomolecules. 2023Nov 11; 13(11):1638 doi: 10.3390/biom13111638. PMID: 38002320; PMCID: PMC10669788.

    Patricia Sinclair, Nadine Kabbani. “Ionotropic and metabotropic responses by alpha 7 nicotinic acetylcholine receptors. Pharmacological Research. 2023 Nov;197:106975. doi:10.1016/j.phrs.2023.106975. Epub 2023 Oct 29. PMID: 38032294.

     Patricia Sinclair, Julia Hakeem, Sreehari G. Kumar, Dominik Loser, Kushan Dixit, Marcel Leist, Udo Kraushaar, Nadine Kabbani. “Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid.” Pesticide Biochemistry and Physiology. 2023 Aug;194:105473. doi: 10.1016/j.pestbp.2023.105473. Epub 2023 May 19. PMID: 37532312.

     Patricia Sinclair and Nadine Kabbani. “Nicotinic receptor components of amyloid beta 42 proteome regulation in human neural cells.” PLOS One. 2022 Aug 12;17(8):e0270479. doi: 10.1371/journal.pone.0270479. PMID: 35960729; PMCID: PMC9374227.

     Patricia Sinclair, Ancha Baranova, Nadine Kabbani. “Mitochondrial disruption by A𝛽42 identified by proteomics and pathway mapping.” Cells. 2021 Sep 10;10(9):2380. doi: 10.3390/cells10092380. PMID: 34572029; PMCID: PMC8468661.

    Contact Info

    Dr. Patricia Sinclair
    Name
    Dr. Patricia Sinclair
    Preferred Pronouns
    she/her
    Job Title
    Assistant Professor, Interdiscplinary Program in Neuroscience
    Phone Number
    703-993-3574
    Office Number
    KB 207

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