Faculty & Staff Directory
Raymond E. Hulse
- Associate Professor
Contact Info
- Name
- Dr. Raymond E. Hulse
- Job Title
- Associate Professor
- Office Number
- Kransnow Institute
Affiliations
Departments
Research Areas
- Neuroscience
Education
University of Illinois, Chicago – B.A., LAS
University of Chicago, - Ph.D., Neurobiology
Boston Children’s Hospital/HMS - post-doctoral studies
Janelia Research Campus - post-doctoral studies
About
How do cells work and what roles do membrane proteins play? My work has focused on the biophysics of ion channels and how they help cells and organelles function. I trained in structural biology and spectroscopy of ion channels and voltage sensors at the University of Chicago in Dr. Eduardo Perozo’s laboratory. I conducted postdoctoral research with Dr. David Clapham at both Boston Children’s Hospital and HHMI’s Janelia Research Campus. There I combined structural and functional approaches with super-resolution microscopy and proteomics to investigate TRP channels, their regulation and contributions to cellular signaling.
Current Research
• Understanding the role of ion channels and membrane proteins in primary cilia function.
• Understanding how AI can be used (uplift) in ion channel and membrane protein studies and genetically encoded sensor design
Teaching Focus
• Structural biology, biophysics, cellular biology and bioinformatics
Classes Neur 601 Neur 328
Selected Publications
- Kunkler PE, Hulse RE, Schmitt M, Nicholson C, Kraig RP (2005) “Optical current source density analysis in hippocampal organ culture shows spreading depression occurs with uniquely reversing currents” J Neuroscience Apr 13(15):3952-3961.
- Hulse RE, Kunkler PE, Swenson W, Kraig RP (2008) “Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-α” J Neuroscience Nov 28(47):12199-12211.
- Hulse RE, Li Q, Perozo E (2010) “Up a Hydrophobic Creek with a Short Paddle” Cell Aug;142(4):515-516.
- Dalmas O, Hyde HC, Hulse RE, Perozo E (2012) “Symmetry-constrained Analysis of Pulsed Double Electron-Electron (DEER) Spectroscopy Reveals the Dynamic Nature of the KcsA Activation Gate” J Am. Chem. Soc. Oct 3;134(39):16360-16369.
- Cruijsen van der E, Nand D, Weingarth M, Prokofyev A, Hornig S, Bonvin A, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M (2013) “The importance of the lipid-pore loop interface for potassium channel structure and function” Proceedings of the National Academy of Sciences Aug 6;110(32):13008-13013.
- Li Q, Wanderling S, Paduch M, Medovoy D, Villalba-Galea C, Hulse RE, Roux B, Kossiakoff A, Perozo E (2014) “Structural Mechanism of Voltage-Dependent Gating in an Isolated Voltage-Sensing Domain” Nature Structure & Molecular Biology Mar;21(3):244-252.
- Hulse RE, Sachleben JR, Wen P-C, Moradi M, Tajkhorshid E, and Perozo E (2014) “Conformational Dynamics at the Inner Gate of KcsA During Activation” Biochemistry Apr 29;53(16):2557-2559.
- Cruijsen van der E, Koers EJ, Sauvée C, Hulse RE, Weingarth M, Ouari O, Perozo E, Tordo P, Baldus M (2015) “Biomolecular DNP-supported NMR spectroscopy using site-directed spin labeling” Chemistry Sep 7;21(37):12971-12977.
- Hulse RE, Li Z, Huang R, Zhang J, Clapham DE (2018) “Cryo-EM structure of the polycystin 2-l1 ion channel” eLife Jul 13;7:e36931.
- Zhang J, Li Z, Duan J, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Clapham DE (2018) “Structure of the mammalian transient receptor potential ion channel, TRPM7” PNAS Aug 28;115(35):E8201-E8210.
- Clapham DE, Hulse RE (2021) “Sperm CatSper ion channels swims into sharper focus.” Nature Jul;595(7869):654-655.
ORCID ID: https://orcid.org/0000-0002-0110-3752
Contact Info
- Name
- Dr. Raymond E. Hulse
- Job Title
- Associate Professor
- Office Number
- Kransnow Institute