My laboratory focuses on host:pathogen interactions of viruses that cause human disease and the impact of those interactions on disease progression at the cell and tissue level. The foundational research aspects of my work focus on innate immune responses elicited during infections and the influence of viral targets on shaping host responses. We employ transcriptomic and proteomic approaches to discover high-value host targets that can influence translational outcomes, including the development of broad-spectrum therapeutic options. Our omic approaches are also geared towards the identification of progressively dynamic biomarkers of disease states and therapeutic efficiency. We also leverage machine-learning based approaches to integrate and analyze multiomic datasets and prioritize host response events that significantly influence disease progression. Our translational and foundational studies leverage multiple preclinical experimental models including simple 2-dimensional cell culture and complex microphysiological systems (organs on chips) to understand human disease caused by viral infections in a clinically relevant context and to evaluate the significance, relevance and efficiency of therapeutic intervention strategies at the multicellular tissue level.