Faculty & Staff Directory
- Assistant Professor
Biophysics, Ohio University (2011)
I am working as an Assistant Professor in School of system biology my main research is focused on Calcium dynamics, Markov chain models and Cell signaling pathways.
My research interests lie in the area of multi-scale computational biomedicine.
Cardiac Calcium Dynamics:
My main research focus has been to use systems biology and multi-scale modeling approaches to understand the role of channel proteins, ion concentrations, and other intra- and intercellular signaling pathways in cardiac diseases caused by genetic mutation or gene expression changes such as arrhythmias.
Modulation of α7 Nicotinic Receptor Intracellular Calcium:
Our motivation is also to develop next generation biophysical models that will study the effects of α7 nicotinic receptors and α4β7 on seizure and epilepsy.
Calcium Signaling in Neurodegenerative Diseases:
In addition to the existing projects in our lab, I am planning to work on the computational modeling for neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). These disorders present an enormous medical, social, financial and scientific problem. Overwhelming evidence suggests that neuronal Ca2+ signaling is abnormal in many of these diseases. However, the roles of aberrant neuronal Ca2+ signaling in the pathogenesis of neurodegenerative disorders are not well understood.
An introduction to systems biology.
Introduction to biochemical systems topics include Mathematical modeling, static network Models, mathematics of biological systems, signaling systems, population systems, and Physiological modeling: the heart as an example.
- McCoy, M. D., A. Ullah, W. J. Lederer and M. S. Jafri (2022). "Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte." Biomolecules 13(1): 72.
- Paudel, R., M. S. Jafri and A. Ullah (2022). "The Role of Ca2+ Sparks in Force Frequency Relationships in Guinea Pig Ventricular Myocytes." Biomolecules 12(11): 1577.
- Paudel, R., M. S. Jafri and A. Ullah (2023). "Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+ 5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model." Genes 14(1): 23.
- Ullah, A., M. T. Hoang-Trong, W. J. Lederer, R. L. Winslow and M. S. Jafri (2022). "Critical Requirements for the Initiation of a Cardiac Arrhythmia in Rat Ventricle: How Many Myocytes?" Cells 11(12): 1878.
- Alomair, L., F. Almsned, A. Ullah and M. S. Jafri (2021). "In silico prediction of the phosphorylation of NS3 as an essential mechanism for dengue virus replication and the antiviral activity of quercetin." Biology 10(10): 1067.
- Hoang-Trong, M. T., A. Ullah, W. J. Lederer and M. S. Jafri (2021). "Cardiac alternans occurs through the synergy of voltage-and calcium-dependent mechanisms." Membranes 11(10): 794.
- Hoang-Trong, T. M., A. Ullah, W. J. Lederer and M. S. Jafri (2021). "A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation." Membranes 11(12): 989.
- King, J. R., A. Ullah, E. Bak, M. S. Jafri and N. Kabbani (2018). "Ionotropic and metabotropic mechanisms of allosteric modulation of α7 nicotinic receptor intracellular calcium." Molecular Pharmacology 93(6): 601-611.