Faculty & Staff Directory
Dmitri Klimov
- Professor
Contact Info
- Name
- Dmitri Klimov
- Job Title
- Professor
- Phone Number
- Office Number
- Colgan Hall, Room 328B, MSN 5B3
Affiliations
Departments
- School of Systems Biology (Instructional Faculty)
Education
- Ph. D. (Physics), Moscow State University, 1992
- M.Sc. (Physics), Moscow State University, 1989
Current Research
In our laboratory we are working on two aspects of biomolecular simulations. First, we are applying various simulation methods to understand the kinetics of formation of amyloid fibril structures at molecular level. Second, we are interested in structural transitions in proteins, which are caused by the application of external mechanical force. Both directions are of immense biophysical and biomedical importance, because they may help to find therapeutic approaches against Alzheimers and other amyloid related diseases or to describe several important cellular processes, such as cell adhesion or cytoskeleton elasticity. To learn more about our research please follow the link Research Interests.
Teaching Focus
- BINF 741 "Introduction to computer simulations of biomolecules"
- BINF740/PHYS630 "Introduction to biophysics"
- BINF690 "Numerical methods in bioinformatics"
Selected Publications
- Honeycutt, J.D., Thirumalai, D., & Klimov, D.K. (1989) Polymer chains in porous media. J. Phys. A22, L169-L175.
- Klimov, D.K. & Khokhlov, A. R. (1992) Study of polymer chain in a solution of colloidal particles. Polymer 33, 2177-2181.
- Klimov, D.K. & Thirumalai, D. (1996) A criterion that determines the foldability of proteins. Phys. Rev. Lett. 76, 4070-4073.
- Klimov, D.K. & Thirumalai, D. (1996) Factors governing the foldability of proteins. Proteins Struct. Funct. Gen. 26, 411-441.
- Klimov, D. K. & Thirumalai, D. (1997) Viscosity dependence of folding rates of proteins. Phys. Rev. Lett. 79, 317-320.
- Veitshans, T., Klimov, D. K., Thirumalai, D. (1997) Protein folding kinetics: Time scales, pathways, and energy landscapes in terms of sequence dependent properties. Folding & Design 2, 1-22.
- Thirumalai, D., Klimov, D. K., Woodson, S. A. (1997) Kinetic partitioning mechanism as unifying theme in the folding of biomolecules. Theor. Chem. Acct. 1, 23-30.
- Klimov, D.K. & Thirumalai, D. (1998) Linking rates of folding in lattice models of proteins with underlying thermodynamic characteristics. J. Chem. Phys. 109, 4119-4125.
- Thirumalai, D., Klimov, D.K., & Betancourt, M.R. (1998) Exploring the folding mechanisms of proteins using lattice models. In: Monte Carlo Approach to Biopolymers and Protein Folding. Edited by P. Grassberger, G. T. Barkema, W. Nadler. Singapore: World Scientific, pp. 19-28.
- Klimov, D.K. & Thirumalai, D. (1998) Cooperativity in protein folding: From lattice models with side chains to real proteins. Folding & Design 3, 127-139.
Contact Info
- Name
- Dmitri Klimov
- Job Title
- Professor
- Phone Number
- Office Number
- Colgan Hall, Room 328B, MSN 5B3