Nadine Kabbani
- Associate Professor
- Associate Chair for Research, Interdisciplinary Program in Neuroscience
Contact Info

- Name
- Dr. Nadine Kabbani
- Job Title
- Associate ProfessorAssociate Chair for Research, Interdisciplinary Program in Neuroscience
- Phone Number
- Office Number
- Krasnow Institute, Room 233, MSN 2A1
Affiliations
Departments
- School of Systems Biology (Research Faculty)
- Neuroscience Program (Research Faculty)
Other Affiliations
- Schar School for Policy and Government
- Center for Biomedical Science and Policy
Centers
- Institute for Biohealth Innovation
Research Areas
- Neuroscience
- Pharmacology
- Science Policy
Education
PhD, Pharmacology, Penn State College of Medicine, (2003)
BS, George Mason University, (1997)
About
Dr. Nadine Kabbani is a neuroscientist and pharmacologist whose research focuses on molecular neuroscience, immune signaling, and public health. She earned her Ph.D. in pharmacology from the Penn State College of Medicine and completed postdoctoral training in neurobiology at Yale University and the Institut Pasteur in Paris.
Since joining George Mason University in 2008, Dr. Kabbani has directed a research laboratory investigating the nicotinic acetylcholine receptor (nAChR), a receptor involved in cholinergic signaling throughout the body. Her group was the first to identify and characterize a non-canonical signaling pathway through which nAChRs interact with G proteins, establishing a metabotropic role for the receptor in neural and immune cell function.
Her current research examines how microglia and peripheral immune cells respond to compounds such as nicotine and cannabinoids. Using mass spectrometry-based proteomics and cellular imaging techniques, her lab is identifying molecular signatures of drug exposure and contributing to collaborative efforts investigating the mechanisms of neuropathic pain and fentanyl toxicity in preclinical models. Her team is also developing artificial intelligence tools for the analysis of immune cell imaging data, with the goal of supporting research in neuroimmune therapeutics.
Dr. Kabbani holds an affiliate faculty position with the Schar School of Policy and Government, where she participates in interdisciplinary studies exploring the effects of substance use, addiction, and environmental exposures on public health.
Teaching Focus
Cellular and Molecular Neuroscience, Neuropharmacology, Neuroscience and Society
Selected Publications
https://scholar.google.com/citations?user=Aip4aXEAAAAJ&hl=en
N. Kabbani, R. Nichols. Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors. Trends in Pharmacol Sci. 2018 39(4):354-366.
N. Kabbani and J. Olds. Nicotinic receptor targeting in physiological and environmental vulnerability: A whole of biosphere perspective. Sci Total Environ 2021; 780:146642.
P. Sinclair and N. Kabbani. Ionotropic and Metabotropic Nicotinic Receptor Signaling. Pharmacol Res. 2023, 197:106975
A. Graur, P. Sinclair, A.K. Schneeweis, D.T. Pak DT, N. Kabbani. The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Sci Rep 2023, 13(1):11434.
A. Graur, A. Haymond, K.H. Lee, F. Viscarra, P. Russo, A. Luchini, M. Paige, I. Bermudez-Diaz, N. Kabbani. Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein. ACS Chem Neurosci 2024 5(11):2322-2333.
A. Graur, P. Sinclair, A. Nusir, N. Erickson, N. Kabbani. HIV-1 gp120 interactions with nicotine modulate mitochondrial function and amyloid release in microglia. Neurochem Res 2025 24;50(2):103.
P. Sinclair, W. Jeffries, N. Lebert, M. Saeed, A. Ullah, N. Kabbani. A predictive machine learning model for cannabinoid effect based on image detection of reactive oxygen species in microglia. PLoS One 2025 Mar 25;20(3):e0320219.
Contact Info

- Name
- Dr. Nadine Kabbani
- Job Title
- Associate ProfessorAssociate Chair for Research, Interdisciplinary Program in Neuroscience
- Phone Number
- Office Number
- Krasnow Institute, Room 233, MSN 2A1