Faculty & Staff Directory
- Associate Professor
Ph.D. Biochemistry, Massachusetts Institute of Technology (MIT)
Dr. Hakami obtained his Ph.D. in Biochemistry in the laboratory of the Nobel Laureate Professor Har Gobind Khorana at the Massachusetts Institute of Technology (MIT), and was subsequently awarded a NRSA fellowship from NIH to complete postdoctoral training at Harvard Medical School (HMS). He is currently an Associate Professor of Microbiology and Infectious Diseases at GMU. The main focus of research in Dr. Hakami’s laboratory is to understand the fundamental mechanisms by which vesicular trafficking within the host regulates innate immune responses during infection with pathogenic agents. In particular, a major focus is the molecular mechanisms by which exosomes, a subtype of extracellular vesicles (EVs), regulate innate immunity. The broad goal of these studies is identifying new strategies for development of highly effective host-based countermeasures.
Regulation of innate immunity through intracellular and extracellular vesicle (exosome) trafficking, Molecular basis of coordinated host signaling response to pathogens, Development of novel therapeutic and vaccine strategies
- The Carrying Pigeons of the Cell: Exosomes and their Role in Diseases Caused by Human Pathogens. A. Fleming, G. Sampey, M.-C. Chung, C. Bailey, M. van Hoek, F. Kashanchi, and R.M. Hakami* (2014) Pathogens and Disease, 2,109-20.
- Presence of viral RNA and proteins in exosomes from the cellular clones resistant. Ahsan, G.C. Sampey, B. Lepene, Y. Akpamagbo, R.A. Barclay, S. Iordanskiy, R.M. Hakami*, and F. Kashanchi* (2016) Front Microbiol., 7:139.
- Extracellular vesicles from infected cells: potential for direct pathogenesis. A. Schwab, S.S. Meyering, B. Lepene, S. Iordanskiy, M.L. van Hoek, R.M. Hakami*, and F. Kashanchi* (2015) Front Microbiol., 6:1132.
- Exosomes and their role in CNS viral infections. G. Sampey, S. Meyering, M. Zadeh, Saifuddin, R.M. Hakami*, and F. Kashanchi* (2014) J. Neurovirol., 20(3), 199-208.
- Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways. F. Alem, K. Yao, D. Lane, V. Calvert, E.F. Petricoin, L. Kramer, M.L. Hale, S. Bavari, R.G. Panchal, and R.M. Hakami* (2015) Front Microbiol., 6:50.
- Multi-Faceted Proteomic Characterization of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Important Viral Host Factors. J.E. Nuss, K. Kehn-Hall, A. Benedict, J. Costantino, M. Ward, B.D. Peyser, L.E. Tressler, L.M. Wanner, H.F. McGovern, A. Zaidi, S. Anthony, K.P. Kota, S. Bavari, and R.M. Hakami* (2014) PloS ONE, 9(5):e93483.
- M-C. Chung, F. Alem, S.G. Hamer, A. Narayanan, K. Shatalin, C. Bailey, E. Nudler, and R.M. Hakami* (2016). S-nitrosylation of Peroxiredoxin 1 Contributes to Viability of Lung Epithelial Cells during Bacillus anthracis Infection. Biochimica et Biophysica Acta, General Subjects, 1861, 3019–3029.
2016 Nominated for the Office of Scholarship, Creative Activities, and Research Excellence Award, George Mason University, VA
2016 Guest editor by invitation from Frontiers in Microbiogy journal for a special topic on the role of exosomes during infectious diseases
2015 Nominated for the Office of Scholarship, Creative Activities, and Research Excellence Award, George Mason University, VA
2014 Elected to the editorial board of the PLoS ONE journal
2003 Fellows Award for Research Excellence, National Institutes of Health, MD
1989 Outstanding Leadership and Service Award, Stony Brook University, NY
1989 American Institute of Chemists Outstanding Senior Award
1989 Undergraduate Excellence Award, Stony Brook University, NY
1988 Undergraduate Excellence Award, Stony Brook University, NY
1988 George Emerson Outstanding Junior Award, Stony Brook University, NY