Faculty & Staff Directory
Fatah Kashanchi
- Professor, Virology
- Director of the Laboratory of Molecular Virology
Contact Info
- Name
- Dr. Fatah Kashanchi
- Job Title
- Professor, VirologyDirector of the Laboratory of Molecular Virology
- Website
- Phone Number
- Office Number
- Discovery Hall, Room 182, MSN 1H8
Affiliations
Departments
- School of Systems Biology (Research Faculty)
Research Areas
- Applied Science
- Biology
- Biomedical Research
- Computer Science
- Medical Proteomics
- Modeling
- Neuroscience
- Personalized Medicine
- Pre-Med
- Microbiology
Education
PhD, Microbiology, University of Kansas, 1991
MS, Emporia State University, 1985BS,
Missouri State University, 1983
About
Dr. Kashanchi received his PhD in 1991 in Microbiology with emphasis on retrovirus gene expression. He worked with Dr. C. Wood on HIV-1 gene expression, who was a student of Nobel Laurette Dr. Tongawa (1987) on B-cell development and gp120 ELISA. He then moved to Washington, DC for his Postdoctoral and Research Associate fellowship at National Cancer Institute, National Institutes of Health from 1991-1998. He was tenured at the George Washington University medical school as a full Professor in 2004. He moved to GMU as director of research in 2010 and stayed at that position until 2013. He is currently the director of the Laboratory of Molecular Virology located at GMU- Sic-Tech campus.
Current Research
Research interests include human retroviruses, biodefense viral agents, Cell cycle, host-pathogen interactions, small molecule and peptide inhibitors against transcription machinery, RNAi machinery and its components, proteomics and metabolomics, humanized mouse models, and extracellular vesicles, including exosomes.
Currently working with:
- Extracellular Vesicles and HIV-1 Pathogenesis
- Ebola virus VP40 and Exosomes
- Humanized mouse models
- Inhibitors of transcription and other related pathways
Teaching Focus
Dr. Kashanchi teaches the Emerging Infectious Disease course (BIOL 685) or Scientific Grant Writing (BIOS 703/ BIOL 691) in the Fall semester. In addition to these courses, he teaches/facilitates the Colloquium Series (BIOL695/ BIOS 704/ BINF 704).
Selected Publications
Selected from 263 PubMed manuscripts (h index = 76)
- Molnar SM, Kim Y, Wieczorek L, et al. Extracellular vesicle isolation methods identify distinct HIV-1 particles released from chronically infected T-cells. J Extracell Vesicles. 2024;13(7):e12476. doi:10.1002/jev2.12476. https://pubmed.ncbi.nlm.nih.gov/38978287/
- Hindle J, Williams A, Kim Y, et al. hTERT-Immortalized Mesenchymal Stem Cell-Derived Extracellular Vesicles: Large-Scale Manufacturing, Cargo Profiling, and Functional Effects in Retinal Epithelial Cells. Cells. 2024;13(10):861. Published 2024 May 17. doi:10.3390/cells1310086. https://pubmed.ncbi.nlm.nih.gov/38786083/
- Muskan M, Abeysinghe P, Cecchin R, Branscome H, Morris KV, Kashanchi F. Therapeutic potential of RNA-enriched extracellular vesicles: The next generation in RNA delivery via biogenic nanoparticles. Mol Ther. 2024;32(9):2939-2949. doi:10.1016/j.ymthe.2024.02.025. https://pubmed.ncbi.nlm.nih.gov/38414242/
- Pleet ML, DeMarino C, Stonier SW, Dye JM, Jacobson S, Aman MJ, Kashanchi F. Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion.Viruses. 2019 May 2;11(5). pii: E410. doi: 10.3390/v11050410. Review.
- Pinto DO, Scott TA, DeMarino C, Pleet ML, Vo TT, Saifuddin M, Kovalskyy D, Erickson J, Cowen M, Barclay RA, Zeng C, Weinberg MS, Kashanchi F. Effect of transcription inhibition and generation of suppressive viral non-coding RNAs. Retrovirology. 2019 Apr 29;16(1):13. doi: 10.1186/s12977-019-0475-0
- Pleet ML, Branscome H, DeMarino C, Pinto DO, Zadeh MA, Rodriguez M, Sariyer IK, El-Hage N, Kashanchi F. Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. Front Cell Infect Microbiol. 2018 Oct 18;8:362. doi: 10.3389/fcimb.2018.00362. eCollection 2018. Review.
- Pleet ML, Erickson J, DeMarino C, Barclay RA, Cowen M, Lepene B, Liang J, Kuhn JH, Prugar L, Stonier SW, Dye JM, Zhou W, Liotta LA, Aman MJ, Kashanchi F, Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles. J Infect Dis. 2018 Aug 30. doi: 10.1093/infdis/jiy472.
- DeMarino C, Pleet ML, Cowen M, Barclay RA, Akpamagbo Y, Erickson J, Ndembe N, Charurat M, Jumare J, Bwala S, Alabi P, Hogan M, Gupta A, Hooten NN, Evans MK, Lepene B, Zhou W, Caputi M, Romerio F, Royal W 3rd, El-Hage N, Liotta LA, Kashanchi Antiretroviral Drugs Extracellular Vesicles from HIV-1-Infected Cells. Sci Rep. 2018 May 16;8(1):7653. doi: 10.1038/s41598-018-25943-2.
- Purification of High Yield Extracellular Vesicle Preparations Away from Virus
Awards
- R01 MH134389, Cell-derived extracellular vesicle mediated epigenetic silencing of HIV in the brain: NIMH, NINDS, Dates of Award 8/2/2023 - 5/31/2028
- VIPC/CCF/extracellular vesicles, Virginia Innovation Partnership Corporation (5/2023 - 4/2024)
- R56, Parasite-Derived Vesicles in Babesia virulence and Vaccine Development, NIAID, 8/1/2024 - 7/31/2025
- R43, An Ultrasensitive Flow Cytometry System for Multiparametric Analysis of Therapeutic Anti-Aging Extracellular Vesicles, NIGMS, 8/15/2024 - 2/14/2025
Co-Organizer and President of the American Society for Intercellular Communication (ASIC)
This Society holds an annual meeting in October. The meeting was organized in 2021 by a group of investigators seeking to create a platform for informal exchange of ideas on emerging questions and cutting-edge developments in the field of Extracellular Vesicles (EVs), Extracellular Particles (EPs), and particulate carriers of extracellular RNA (exRNA) as biological mediators, regulators, and diagnostic analytes. |
Contact Info
- Name
- Dr. Fatah Kashanchi
- Job Title
- Professor, VirologyDirector of the Laboratory of Molecular Virology
- Website
- Phone Number
- Office Number
- Discovery Hall, Room 182, MSN 1H8